Vps34-IN-4

Vps34-IN-4

• CAS Number: 1383716-46-8
• UNSPSC Description: Vps34-IN-4 (compound 19) is a potent, selective, and orally active inhibitor of VPS34. Vps34-IN-4 inhibits the autophagy in vivo. Autophagy is a dynamic process that regulates lysosomal-dependent degradation of cellular components[1].
• Target Antigen: Autophagy; PI3K
• Type: Reference compound
• Related Pathways: Autophagy;PI3K/Akt/mTOR
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/vps34-in-4.html
• Purity: 99.19
• Solubility: DMSO : 78 mg/mL (ultrasonic)
• Smiles: CC(O)(C)CNC1=NC=C(C2=NC(NC3=CC=NC=C3)=NC=C2)C(CC4CC4)=N1
• Molecular Weight: 391.47
• References & Citations: [1]Honda A, et al. Potent, Selective, and Orally Bioavailable Inhibitors of VPS34 Provide Chemical Tools to Modulate Autophagy in Vivo. ACS Med Chem Lett. 2015;7(1):72-76.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C, 3 years (Powder)
• Clinical Information: No Development Reported