Vps34-IN-4

• UNSPSC Description:

  Vps34-IN-4 (compound 19) is a potent, selective, and orally active inhibitor of VPS34. Vps34-IN-4 inhibits the autophagy in vivo. Autophagy is a dynamic process that regulates lysosomal-dependent degradation of cellular components[1].

• Target Antigen:

  Autophagy; PI3K

• Type:

  Reference compound

• Related Pathways:

  Autophagy;PI3K/Akt/mTOR

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/vps34-in-4.html

• Purity:

  99.19

• Solubility:

  DMSO : 78 mg/mL (ultrasonic)

• Smiles:

  CC(O)(C)CNC1=NC=C(C2=NC(NC3=CC=NC=C3)=NC=C2)C(CC4CC4)=N1

• Molecular Weight:

  391.47

• References & Citations:

  [1]Honda A, et al. Potent, Selective, and Orally Bioavailable Inhibitors of VPS34 Provide Chemical Tools to Modulate Autophagy in Vivo. ACS Med Chem Lett. 2015;7(1):72-76.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1383716-46-8