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BB-Cl-Amidine

CAT: 0026-B2847-5Size: 5 mgDry Ice: NoHazardous: No
CAT#:0026-B2847-5Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BB-Cl-Amidine is a pan-peptidylarginine deiminase (PAD) inhibitor. Peptidylarginine deiminase catalyzes the hydrolysis of peptidyl-arginine to form peptidyl-citrulline. BB-Cl-Amidine is a derivative of the PAD inhibitor Cl-amidine in which the C-terminal carboxamide is replaced with a benzimidazole moiety to reduce proteolysis. The cellular potency of BB-Cl-amidine is 20-fold higher than Cl-amidine. The EC₅₀ value for inhibition of viability of U2OS osteosarcoma cells is 8.8 μM. It improves endothelium-dependent vasorelaxation in MRL/lpr mice. It inhibits the formation of neutrophil extracellular traps without altering H₂O₂ production by neutrophils.
Shipping Conditions
Gel Pack
Storage Conditions
-20ºC
Shelf Life
36 months

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