Pifithrin-µ

CAT: 0026-B1083-25Size: 25 mgDry Ice: NoHazardous: No
CAT#:0026-B1083-25Size:25 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Pifithrin-μ (PFT-μ) is an inhibitor of p53-mediated apoptosis, preventing p53 binding to Bcl-xL and Bcl-2 at the mitochondria without affecting p53 transactivational activities. In vitro, PFT-μ binds both p53 (Kd = 0.82 mM) and Bcl-xL (Kd = 0.80 mM). It reduces p53-mediated apoptosis induced by γ-radiation in mouse thymocytes in vitro and protects mice from doses of radiation that cause lethal hematopoietic syndrome. At 25 μM, PFT-μ reduces apoptosis triggered by nutlin-3, which inhibits MDM2/p53 binding and potentiates p53-mediated growth arrest and apoptosis.
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
36 months

Alternative Products

CatalogName
BML-GR325-0025Pifithrin-α
MF-0049194-01Pifithrin-?
HY-16702Pifithrin-β
2653/10Pifithrin-μ
BUP14339-01Pifithrin-µ
563407Pifithrin-µ

Popular Products