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SPHINX31

CAT: 0026-B2516-5Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0026-B2516-5Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SPHINX31 is a potent inhibitor of serine/arginine-rich protein kinase 1 (SRPK1) IC₅₀ = 5.9 nM). It displays selectivity for SRPK1 over a panel of 50 kinases at a concentration of 1 μM. SPHINX31 inhibits phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1), an SRPK1 substrate, in PC3 cells (EC50 = 360 nM) and increases expression of the anti-angiogenic VEGF-A165b splice variant in retinal pigment epithelial (RPE) cells.
Shipping Conditions
Gel Pack
Storage Conditions
-20ºC
Shelf Life
36 months

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