CCT-196969

CAT: 0026-B2500-25Size: 25 mgDry Ice: NoHazardous: No
CAT#:0026-B2500-25Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CCT-196969 is a pan-Raf inhibitor, which inhibits B-Raf, BRafV600E and CRAF with IC₅₀s of 0.1, 0.04, and 0.01 μM, respectively. It is selective for RAFs, Src, LCK, and MAPKs in a panel of 63 kinases when used at a concentration of 1 μM. CCT-196969 inhibits MEK and ERK signaling in B-RAF mutant WM266.4 cells, but not B-RAF wild-type D35 cells, and inhibits growth of B-RAF mutant melanoma cells in a concentration-dependent manner.
Shipping Conditions
Gel Pack
Storage Conditions
-20ºC
Shelf Life
36 months

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