Cdk5i peptide

• Description:

  Cdk5i peptide is a CDK5 inhibitory peptide with high binding affinity for Cdk5/p25 (Kd of 0.17 μM), which can block the interaction between CDK5 and p25 and reduce the kinase activity of CDK5/p25. Cdk5i peptide can be used in the stud y of neurodegenerative diseases[1].

• UNSPSC:

  12352209

• Target:

  CDK

• Type:

  Peptides

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/cdk5i-peptide.html

• Purity:

  99.83

• Solubility:

  DMSO : 2 mg/mL (ultrasonic)

• Smiles:

  O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CC1=CC=CC=C1)C(NCC(N[C@@H]([C@@H](C)CC)C(N2[C@@H](CCC2)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CS)C(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N

• Molecular Formula:

  C60H94N18O15S

• Molecular Weight:

  1339.56

• References & Citations:

  [1]Pao PC, et al. A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes. Proc Natl Acad Sci U S A. 2023 Apr 18;120 (16) :e2217864120.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• Isoform:

  CDK5

• CAS Number:

  2298317-00-5