LH2 peptide

• Description:

  LH2 peptide is a pH-responsive cell-penetrating peptide dimer with the amino acid sequence LHHLCHLLHHLCHLAG. It can increase its uptake in tumor cells under weakly acidic conditions (such as the tumor microenvironment) through the protonation of histidine residues (pKa approximately 6) . When conjugated with the anticancer drug Paclitaxel (HY-B0015), the PTX-LH2 conjugate showed superior tumor suppression effects compared to paclitaxel alone in a subcutaneous breast tumor model. The LH2 peptide holds potential as a drug delivery vehicle in cancer research[1].

• UNSPSC:

  12352209

• Target:

  Others

• Related Pathways:

  Others

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Smiles:

  O=C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CC2=CNC=N2)C(N[C@@H](CC(C)C)C(N[C@@H](CS)C(N[C@@H](CC3=CNC=N3)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC4=CNC=N4)C(N[C@@H](CC5=CNC=N5)C(N[C@@H](CC(C)C)C(N[C@@H](CS)C(N[C@@H](CC6=CNC=N6)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)N

• Molecular Formula:

  C83H128N28O17S2

• Molecular Weight:

  1854.21

• References & Citations:

  [1]Kim J Y, et al. Combination of peptides with biological, organic, and inorganic materials for synergistically enhanced diagnostics and therapeutics[J]. Peptide Science, 2022, 114 (3) : e24233.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported