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Aldose Reductase Activity Kit (Colorimetric)

CAT: 0026-K369-100Size: 100 AssaysDry Ice: NoHazardous: No
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CAT#:0026-K369-100Size:100 Assays
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Aldose Reductase (Aldehyde Reductase; AR; ALR2; EC 1.1.1.21), a member of the aldo-keto reductase superfamily, catalyzes the NADPH-dependent reduction of a wide variety of aldoses (molecules containing carbonyl groups) to their corresponding alcohols. It is a key enzyme in the polyol (polyhydric alcohol) pathway and has been implicated to play a critical role in diabetes and cardiovascular complications. Aldose Reductase is the key factor in the reduction of glucose to sorbitol and its activity is higher during hyperglycemic conditions. The synthesis and accumulation of sorbitol due to AR activity is the main cause of diabetic complications, such as cataracts, retinopathy, neuropathy and nephropathy. Thus, AR could be used as a therapeutic target for the clinical treatment of secondary complications of diabetes. BioVision’s Aldose Reductase Activity Kit is based on the ability of AR to catalyze the oxidation of NADPH. The reaction progress is followed by monitoring the decrease in absorbance at 340 nm. The assay has been optimized to be monitored using a 96 well plate. The assay is simple, sensitive and can detect as little as 0.1 mU of Aldose Reductase activity in a variety of samples.
Reactivity
All, Mammalian
Applications
Analysis of polyol pathway, Measurement of Aldose Reductase activity in various tissues/cells
Detection Method
Colorimetric assay at 340 nm
Features & Benefits
Can detect as little as 0.1 mU of Aldose Reductase activity in a variety of samples., Simple Procedure, Sensitive Assay to measuring Aldose Reductase activity
Shipping Conditions
Gel Pack
Storage Conditions
-20°C
Shelf Life
12 months

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