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E6AP-mimicking peptide

CAT: 0804-HY-P10428Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P10428Size:1 Each
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Description
E6AP-mimicking peptide (compound 13) is a high-affinity, selective, irreversible and potent peptide-based covalent HPV16 E6 inhibitor targeting the 16E6 oncoprotein using a cysteine-reactive acrylamide warhead. E6AP-mimicking peptide has a Ki of 17 nM. E6AP-mimicking peptide targets all residues appearing in the binding pocket of E6 to disrupt the binding interface of 16E6 and E6AP. E6AP-mimicking peptide selectively binds and crosslinks to MBP-16E6 in PBS or a protein mixture[1].
UNSPSC
12352209
Target
HPV
Type
Peptides
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/e6ap-mimicking-peptide.html
Smiles
C=C(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CCCCNC(C1=C2C=C3C=CC=CC3=CC2=CC=C1)=O)=O)CCCCN)=O)CCCCN)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]([C@H](O)C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCC(N)=O)NC([C@H]4CCCN4C([C@H]([C@@H](C)CC)NC(CC5C(C=CC=C6)=C6C7=C5C=CC=C7)=O)=O)=O)=O)CO)=O)C)=O)CCC(O)=O)=O)CC(C)C)=O)=O)CC(C)C)=O)CCC(N)=O)=O)CCC(O)=O)=O)CC(C)C)=O)CC(C)C)=O
Molecular Formula
C128H193N31O29
Molecular Weight
2630.09
References & Citations
[1]Xiyun Ye, et al. Discovery of reactive peptide inhibitors of human papillomavirus oncoprotein E6. Chem Sci. 2023 Oct 25;14 (44) :12484-12497.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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