Products for Research Use Only
RegisterLogin

Nonapeptide-1

CAT: 0804-HY-P0097-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-P0097-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Nonapeptide-1 (Melanostatine-5), a peptide hormone, is a selective antagonist of MC1R (Ki: 40 nM) . Nonapeptide-1 is a competitive α-MSH antagonist that potently inhibits intracellular cAMP and melanosome dispersion induced by α-MSH in melanocytes (IC50: 2.5 nM and 11 nM, respectively) . Nonapeptide-1 inhibits melanin synthesis, and can be used in the research of skin pigmentation and regulation of steroid production in the adrenal gland, skin cancer[1][2][3].
CAS Number
158563-45-2
Product Name Alternative
Melanostatine-5
UNSPSC
12352209
Hazard Statement
H302
Target
Melanocortin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Endocrinology; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/nonapeptide-1.html
Purity
99.04
Solubility
H2O : 44.44 mg/mL (adjust pH to 2 with 1 M HCl)
Smiles
O=C(N1[C@@H](CCC1)C(N[C@H](C(N)=O)C(C)C)=O)[C@H](CCCCN)NC([C@H](CC2=CC=CC=C2)NC([C@H](NC([C@H](CCCNC(N)=N)NC([C@@H](CC3=CC=CC=C3)NC([C@H]4N(CCC4)C([C@@H](N)CCSC)=O)=O)=O)=O)CC5=CNC6=CC=CC=C56)=O)=O
Molecular Formula
C61H87N15O9S
Molecular Weight
1206.50
Precautions
H302
References & Citations
[1]Jayawickreme CK, et al. Discovery and structure-function analysis of alpha-melanocyte-stimulating hormone antagonists. J Biol Chem. 1994 Nov 25;269 (47) :29846-54. |[2]Schiöth, H.B., et al. Characterization of the binding of MSH-B, HB-228, GHRP-6 and 153N-6 to the human melanocortin receptor subtypes. Neuropeptides 31 (6), 565-571 (1997) .|[3]Jiaoquan Chen, et al. Effects of tea polyphenols on UVA-induced melanogenesis via inhibition of α-MSH-MC1R signalling pathway. Postepy Dermatol Alergol. 2022 Apr;39 (2) :327-335.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
MC1R; MC3R; MC4R; MC5R

Related Products

CatalogName
HY-P10263MAGE-1 nonapeptide
HY-106783-01Polymyxin B nonapeptide
HY-106783R-01Polymyxin B nonapeptide (Standard)
HY-106783A-01Polymyxin B nonapeptide (TFA)
HY-106783AR-01Polymyxin B nonapeptide (TFA) (Standard)
HY-N6838-011,1,1,1-Kestohexaose
HY-157129AMPK-α1β1γ1 activator 1
HY-1336231,1,1-Tribromoacetone
HY-149536TWIK-1/TREK-1-IN-1
HY-W160628S1,1,1-Trimethoxypropane-d5

Alternative Products

CatalogName
BA5550-5Nonapeptide-1
A23429-200Nonapeptide-1 200mg
A23429-25Nonapeptide-1 25mg
A23429-5Nonapeptide-1 5mg
BN183113-01Nonapeptide 1 acetate
A23429-10Nonapeptide-1 10mg
A23429-100Nonapeptide-1 100mg
A23429-50Nonapeptide-1 50mg
T75715-01Nonapeptide-1 acetate salt
462640-01PinMPA-Nonapeptide

Popular Products