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MMPSI

CAT: 0804-HY-103346-01Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-103346-01Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MMPSI is a potent and selective small molecule caspase 3 and caspase 7 inhibitor with an IC50 of 1.7 μM for human caspase-3. MMPSI can significantly reduce ischemia-reperfusion-induced infarct size in the isolated rabbit heart, and reduce apoptosis in both the ischemic myocardium and isolated cardiomyocytes. MMPSI can be used for researching cardioprotection[1].
CAS Number
220509-74-0
UNSPSC
12352005
Target
Apoptosis; Caspase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Neuroscience-Neurodegeneration
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/mmpsi.html
Concentration
10mM
Purity
99.09
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1NC2=C(C=C(S(=O)(N3[C@H](COC)CCC3)=O)C=C2)C1=O
Molecular Formula
C14H16N2O5S
Molecular Weight
324.35
References & Citations
[1]Chapman JG, et al, Tracey WR. A novel nonpeptidic caspase-3/7 inhibitor, (S) - (+) -5-[1- (2-methoxymethylpyrrolidinyl) sulfonyl]isatin reduces myocardial ischemic injury. Eur J Pharmacol. 2002;456 (1-3) :59-68.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3

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