Adenosine-2'-monophosphate

• Product Name Alternative:

  2'-AMP; Adenosine 2'-phosphate; AMP 2'-phosphate

• UNSPSC Description:

  Adenosine-2'-monophosphate (2'-AMP) is converted by extracellular 2’,3'-CAMP. Adenosine-2'-monophosphate is further metabolized to extracellular adenosine (a mechanism called the extracellular 2’,3’-cAMP-adenosine pathway). Adenosine-2'-monophosphate inhibits LPS-induced TNF-α and CXCL10 production via A2A receptor activation[1][2].

• Target Antigen:

  Adenosine Receptor; Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  GPCR/G Protein;Metabolic Enzyme/Protease

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/adenosine-2-monophosphate.html

• Purity:

  99.91

• Solubility:

  DMSO : 62.5 mg/mL (ultrasonic;warming;heat to 80°C)|H2O : 50 mg/mL (ultrasonic;adjust pH to 7 with NaOH)

• Smiles:

  O=[P](O)(O)O[C@H]([C@@H]1O)[C@@](N2C3=NC=NC(N)=C3N=C2)([H])O[C@@H]1CO

• Molecular Weight:

  347.224

• References & Citations:

  [1]Jackson EK, Gillespie DG, Dubey RK. 2'-AMP and 3'-AMP inhibit proliferation of preglomerular vascular smooth muscle cells and glomerular mesangial cells via A2B receptors. J Pharmacol Exp Ther. 2011;337(2):444‐450.|[2]Newell EA, Exo JL, Verrier JD, et al. 2',3'-cAMP, 3'-AMP, 2'-AMP and adenosine inhibit TNF-α and CXCL10 production from activated primary murine microglia via A2A receptors. Brain Res. 2015;1594:27‐35.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  130-49-4