Adenosine-2'-monophosphate

Adenosine-2'-monophosphate

• Product Name Alternative: 2'-AMP; Adenosine 2'-phosphate; AMP 2'-phosphate
• CAS Number: 130-49-4
• UNSPSC Description: Adenosine-2'-monophosphate (2'-AMP) is converted by extracellular 2’,3'-CAMP. Adenosine-2'-monophosphate is further metabolized to extracellular adenosine (a mechanism called the extracellular 2’,3’-cAMP-adenosine pathway). Adenosine-2'-monophosphate inhibits LPS-induced TNF-α and CXCL10 production via A2A receptor activation[1][2].
• Target Antigen: Adenosine Receptor; Endogenous Metabolite
• Type: Natural Products
• Related Pathways: GPCR/G Protein;Metabolic Enzyme/Protease
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/adenosine-2-monophosphate.html
• Purity: 99.91
• Solubility: DMSO : 62.5 mg/mL (ultrasonic;warming;heat to 80°C)|H2O : 50 mg/mL (ultrasonic;adjust pH to 7 with NaOH)
• Smiles: O=[P](O)(O)O[C@H]([C@@H]1O)[C@@](N2C3=NC=NC(N)=C3N=C2)([H])O[C@@H]1CO
• Molecular Weight: 347.224
• References & Citations: [1]Jackson EK, Gillespie DG, Dubey RK. 2'-AMP and 3'-AMP inhibit proliferation of preglomerular vascular smooth muscle cells and glomerular mesangial cells via A2B receptors. J Pharmacol Exp Ther. 2011;337(2):444‐450.|[2]Newell EA, Exo JL, Verrier JD, et al. 2',3'-cAMP, 3'-AMP, 2'-AMP and adenosine inhibit TNF-α and CXCL10 production from activated primary murine microglia via A2A receptors. Brain Res. 2015;1594:27‐35.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C, 3 years (Powder)
• Clinical Information: No Development Reported