DL-AP5

• Description:

  DL-AP5 (2-APV) is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 shows significantly antinociceptive activity. DL-AP5 specifically blocks on channels in the rabbit retina[1][2][3].

• Product Name Alternative:

  2-APV; DL-2-Amino-5-phosphonovaleric acid

• UNSPSC:

  12352211

• Hazard Statement:

  H315, H319, H335

• Target:

  IGluR

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/dl-ap5.html

• Purity:

  98.0

• Solubility:

  H2O : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  NC(CCCP(O)(O)=O)C(O)=O

• Molecular Formula:

  C5H12NO5P

• Molecular Weight:

  197.13

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Murray CW, et al. Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model. Pain. 1991;44 (2) :179-185.|[2]Massey SC, et al. N-methyl-D-aspartate receptors of ganglion cells in rabbit retina. J Neurophysiol. 1990;63 (1) :16-30.|[3]Jafari-Sabet M. NMDA receptor blockers prevents the facilitatory effects of post-training intra-dorsal hippocampal NMDA and physostigmine on memory retention of passive avoidance learning in rats. Behav Brain Res. 2006 Apr 25;169 (1) :120-7.|[4]Taati M, et al. The effects of DL-AP5 and glutamate on ghrelin-induced feeding behavior in 3-h food-deprived broiler cockerels. J Physiol Biochem. 2011 Jun;67 (2) :217-23.|[5]Chen T, et al. Glutamate-induced rapid induction of Arc/Arg3.1 requires NMDA receptor-mediated phosphorylation of ERK and CREB. Neurosci Lett. 2017 Nov 20;661:23-28.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  NMDA Receptor

• CAS Number:

  [76326-31-3]