D-AP5

• Description:

  D-AP5 (D-APV) is a selective and competitive NMDA receptor antagonist with a Kd of 1.4 μM. D-AP5 (D-APV) inhibits the glutamate binding site of NMDA receptors[1][2].

• Product Name Alternative:

  D-APV; D-2-Amino-5-phosphonovaleric acid

• UNSPSC:

  12352211

• Hazard Statement:

  H315, H319, H335

• Target:

  IGluR

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/D-AP5.html

• Purity:

  99.94

• Solubility:

  DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : < 1 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic)

• Smiles:

  N[C@H] (CCCP (O) (O) =O) C (O) =O

• Molecular Formula:

  C5H12NO5P

• Molecular Weight:

  197.13

• Precautions:

  H315, H319, H335

• References & Citations:

  [3]R H Evans, et al. The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations. Br J Pharmacol. 1982 Jan;75 (1) :65-75.|[1]Davis S, et al. The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro. J Neurosci. 1992 Jan;12 (1) :21-34.|[2]Morris RG, et al. N-methyl-d-aspartate receptors, learning and memory: chronic intraventricular infusion of the NMDA receptor antagonist d-AP5 interacts directly with the neural mechanisms of spatial learning. Eur J Neurosci. 2013 Mar;37 (5) :700-17.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  NMDA Receptor

• CAS Number:

  79055-68-8