D-AP5

D-AP5

• CAS Number: 79055-68-8
• UNSPSC Description: D-AP5 (D-APV) is a selective and competitive NMDA receptor antagonist with a Kd of 1.4 μM. D-AP5 (D-APV) inhibits the glutamate binding site of NMDA receptors[1][2].
• Target Antigen: iGluR
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/D-AP5.html
• Purity: 99.94
• Solubility: DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C)|Ethanol : < 1 mg/mL (ultrasonic)|H2O : 2 mg/mL (ultrasonic)
• Smiles: N[C@H](CCCP(O)(O)=O)C(O)=O
• Molecular Weight: 197.13
• References & Citations: [1]Davis S, et al. The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro. J Neurosci. 1992 Jan;12(1):21-34.|[2]Morris RG, et al. N-methyl-d-aspartate receptors, learning and memory: chronic intraventricular infusion of the NMDA receptor antagonist d-AP5 interacts directly with the neural mechanisms of spatial learning. Eur J Neurosci. 2013 Mar;37(5):700-17.|[3]R H Evans, et al. The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations. Br J Pharmacol. 1982 Jan;75(1):65-75.Biomed Pharmacother. January 2022, 112446.|Brain Behav Immun. 2023 Jun 5;S0889-1591(23)00141-1.|Brain Res. 2019 Dec 15;1725:146487.|Cell Death Discov. 2020 Sep 17;6:87.|CNS Neurosci Ther. 2022 Nov 15.|Environ Sci Technol. 2023 Aug 9.|Exp Brain Res. 2023 Oct 16.|Front Pharmacol. 2022 Jun 9;13:888308.|J Neurochem. 2022 Jul 1.|J Neuroinflammation. 2024 Mar 26;21(1):76.|Neural Plast. 08 Jul 2021.|Neurochem Int. 2023 Jul 24;105587.|Research Square Print. August 24th, 2022.|Sci Rep. 2024 Aug 20;14(1):19337.|Sens Actuators B Chem. 2020, 129190.|Theranostics. 2021 Mar 4;11(10):4616-4636.|Theranostics. 2023 May 11;13(9):2946-2961.|Int J Biol Macromol. 2024 Oct 28:136767.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C, 3 years (Powder)
• Clinical Information: No Development Reported