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D-AP5

CAT: 0804-HY-100714A-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-100714A-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
D-AP5 (D-APV) is a selective and competitive NMDA receptor antagonist with a Kd of 1.4 μM. D-AP5 (D-APV) inhibits the glutamate binding site of NMDA receptors[1][2].
CAS Number
[79055-68-8]
Product Name Alternative
D-APV; D-2-Amino-5-phosphonovaleric acid
UNSPSC
12352211
Hazard Statement
H315, H319, H335
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/D-AP5.html
Purity
99.94
Solubility
DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : < 1 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic)
Smiles
N[C@H](CCCP(O)(O)=O)C(O)=O
Molecular Formula
C5H12NO5P
Molecular Weight
197.13
Precautions
H315, H319, H335
References & Citations
[3]R H Evans, et al. The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations. Br J Pharmacol. 1982 Jan;75 (1) :65-75.|[1]Davis S, et al. The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro. J Neurosci. 1992 Jan;12 (1) :21-34.|[2]Morris RG, et al. N-methyl-d-aspartate receptors, learning and memory: chronic intraventricular infusion of the NMDA receptor antagonist d-AP5 interacts directly with the neural mechanisms of spatial learning. Eur J Neurosci. 2013 Mar;37 (5) :700-17.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NMDA Receptor

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