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CC-223

CAT: 0607-B6171-25Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0607-B6171-25Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
mTOR inhibitor, orally bioavailable
CAS Number
1228013-30-6
Product Name Alternative
7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((1r,4r)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one
Field of Research
PI3K Akt mTOR Signaling mTOR
Purity
0.9867
Form
A crystalline solid
Solubility
insoluble in H2O; ≥108 mg/mL in DMSO; ≥20.28 mg/mL in EtOH
Smiles
O=C1N([C@H]2CC[C@H](OC)CC2)C3=NC(C4=CN=C(C(O)(C)C)C=C4)=CN=C3NC1
Molecular Formula
C21H27N5O3
Molecular Weight
397.47
Shipping Conditions
Blue ice
Storage Conditions
Store at -20°C.

Chemical Information

CC 223

Onatasertib (CC-223) has been used in trials studying the treatment and basic science of Multiple Myeloma, Glioblastoma Multiforme, HepatoCellular Carcinoma, Non-small Cell Lung Cancer, and Diffuse Large B-Cell Lymphoma, among others.

CAS Number1228013-30-6
PubChem CID58298316
IUPAC Name3-[6-(2-hydroxypropan-2-yl)-3-pyridinyl]-5-(4-methoxycyclohexyl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-one
Molecular FormulaC21H27N5O3
Molecular Weight397.5
XLogP1.1
Topological Polar Surface Area100
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Heavy Atom Count29
Formal Charge0
Complexity581
SMILES
CC(C)(C1=NC=C(C=C1)C2=CN=C3C(=N2)N(C(=O)CN3)C4CCC(CC4)OC)O
InChI
InChI=1S/C21H27N5O3/c1-21(2,28)17-9-4-13(10-22-17)16-11-23-19-20(25-16)26(18(27)12-24-19)14-5-7-15(29-3)8-6-14/h4,9-11,14-15,28H,5-8,12H2,1-3H3,(H,23,24)
InChIKey
UFKLYTOEMRFKAD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of CC 223
CAS: 1228013-30-6
CID: 58298316
Formula: C21H27N5O3
MW: 397.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight397.5
XLogP31.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Exact Mass397.21138974
Monoisotopic Mass397.21138974
Topological Polar Surface Area100 Ų
Heavy Atom Count29
Formal Charge0
Complexity581
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
MBS3600884-01CC-223
C18060Onatasertib (CC 223)
A13078-100CC-223 100mg
A13078-25CC-223 25mg
A13078-10CC-223 10mg
A13078-5CC-223 5mg
A13078-50CC-223 50mg
A13078-1CC-223 1mg
SF2798-10mMCC-223 (mTOR inhibitor)
A13078-10mM-DCC-223 10mM * 1mL in DMSO

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