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J-115814

CAT: 0804-HY-122021Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-122021Size:1 Each
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Description
J-115814 is a potent and selective neuropeptide Y1 antagonist with Ki values of 1.4, 1.8, 1.9, >10000, 620, 6000, >10000 nM for hY1, rY1, mY1, hY2, hY4, hY5, mY6, respectively. J-115814 inhibits feeding behaviors[1].
CAS Number
329716-61-2
UNSPSC
12352005
Target
Neuropeptide Y Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/j-115814.html
Smiles
CC1=C(SC(CCC2=CC(N3CCOCC3)=CC(NC(C)C4=CC(NC(OC(C)C)=O)=CC(Cl)=C4)=N2)=N1)CC
Molecular Formula
C29H38ClN5O3S
Molecular Weight
572.16
References & Citations
[1]Kanatani A, et al. A typical Y1 receptor regulates feeding behaviors: effects of a potent and selective Y1 antagonist, J-115814. Mol Pharmacol. 2001 Mar;59 (3) :501-5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NPY Y1 receptor; NPY Y2 receptor; NPY Y4 receptor; NPY Y5 receptor

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