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Pazopanib Hydrochloride

CAT: 0607-A8347-5.1Size: 10 mM (in 1mL DMSO)Dry Ice: NoHazardous: No
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CAT#:0607-A8347-5.1Size:10 mM (in 1mL DMSO)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VEGFR/PDGFR/FGFR/c-Kit/ c-Fms inhibitor
CAS Number
635702-64-6
Product Name Alternative
5-[[4-[(2,3-dimethylindazol-6-yl)-methylamino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide;hydrochloride
Sequence
GW786034;Votrient;Armala;GW 786034;GW-786034
Field of Research
Tyrosine Kinase VEGFR
Purity
0.9855
Form
A solid
Solubility
≥11.1 mg/mL in H2O; ≥11.85 mg/mL in DMSO; ≥2.88 mg/mL in EtOH
Smiles
CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N.Cl
Molecular Formula
C21H24ClN7O2S
Molecular Weight
473.98
Shipping Conditions
Blue ice
Storage Conditions
Store at -20°C.

Chemical Information

Pazopanib Hydrochloride

Pazopanib hydrochloride is a hydrochloride salt prepared from equimolar amounts of pazopanib and hydrochloric acid. Used for treatment of kidney cancer. It has a role as an antineoplastic agent, a tyrosine kinase inhibitor, an angiogenesis modulating agent and a vascular endothelial growth factor receptor antagonist. It contains a pazopanib(1+).

CAS Number635702-64-6
PubChem CID11525740
IUPAC Name5-[[4-[(2,3-dimethylindazol-6-yl)-methylamino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide;hydrochloride
Molecular FormulaC21H24ClN7O2S
Molecular Weight474.0
Topological Polar Surface Area127
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Heavy Atom Count32
Formal Charge0
Complexity717
SMILES
CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N.Cl
InChI
InChI=1S/C21H23N7O2S.ClH/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16;/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25);1H
InChIKey
MQHIQUBXFFAOMK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Pazopanib Hydrochloride
CAS: 635702-64-6
CID: 11525740
Formula: C21H24ClN7O2S
MW: 474.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight474.0
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Exact Mass473.1400719
Monoisotopic Mass473.1400719
Topological Polar Surface Area127 Ų
Heavy Atom Count32
Formal Charge0
Complexity717
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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