Products for Research Use Only
RegisterLogin

MK-0752

CAT: 0607-A4006-10Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0607-A4006-10Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
γ-secretase inhibitor
CAS Number
471905-41-6
Product Name Alternative
3-[4-(4-chlorophenyl)sulfonyl-4-(2,5-difluorophenyl)cyclohexyl]propanoic acid
Sequence
MK 0752, MK0752
Field of Research
Proteases Gamma Secretase
Purity
0.9945
Solubility
≥22.15 mg/mL in DMSO; insoluble in H2O; ≥48.8 mg/mL in EtOH with ultrasonic
Smiles
C1CC(CCC1CCC(=O)O)(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl
Molecular Formula
C21H21ClF2O4S
Molecular Weight
442.9
Shipping Conditions
Blue ice
Storage Conditions
Store at -20°C.

Chemical Information

Mk-0752

Mk 0752 is under investigation in clinical trial NCT00572182 (MK0752 in Treating Young Patients With Recurrent or Refractory CNS Cancer).

CAS Number471905-41-6
PubChem CID9803433
IUPAC Name3-[4-(4-chlorophenyl)sulfonyl-4-(2,5-difluorophenyl)cyclohexyl]propanoic acid
Molecular FormulaC21H21ClF2O4S
Molecular Weight442.9
XLogP4.7
Topological Polar Surface Area79.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Heavy Atom Count29
Formal Charge0
Complexity665
SMILES
C1CC(CCC1CCC(=O)O)(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl
InChI
InChI=1S/C21H21ClF2O4S/c22-15-2-5-17(6-3-15)29(27,28)21(18-13-16(23)4-7-19(18)24)11-9-14(10-12-21)1-8-20(25)26/h2-7,13-14H,1,8-12H2,(H,25,26)
InChIKey
XCGJIFAKUZNNOR-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Mk-0752
CAS: 471905-41-6
CID: 9803433
Formula: C21H21ClF2O4S
MW: 442.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight442.9
XLogP34.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass442.0817143
Monoisotopic Mass442.0817143
Topological Polar Surface Area79.8 Ų
Heavy Atom Count29
Formal Charge0
Complexity665
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
A3615-10MK-3207
BA5198-1MK-5046
A3618-5.1MK-5172
BA5670-100MK-3697
A3100-10(+)-MK 801
A3608-10MK 0893
B7023-10MK-571
A3612-1MK-0974
BA5621-5.1MK-0557
BA1868-1MK-0608

Alternative Products

CatalogName
525670MK-0752
FM101546-01MK 0752

Popular Products