β-Elemonic acid

• Description:

  β-Elemonic acid is a triterpene isolated from Boswellia carterii. β-Elemonic acid induces cell apoptosis, reactive oxygen species (ROS) and COX-2 expression and inhibits prolyl endopeptidase. β-Elemonic acid exhibits anticancer and anti-inflammatory effects[1][2].

• UNSPSC:

  12352211

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Apoptosis; COX; Endogenous Metabolite; Prolyl Endopeptidase (PREP) ; Reactive Oxygen Species (ROS)

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/β-elemonic-acid.html

• Purity:

  99.77

• Solubility:

  DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL

• Smiles:

  C[C@@]12C3=C (CC[C@]1 ([C@@] ([C@@H] (C (O) =O) CC/C=C (C) /C) ([H]) CC2) C) [C@@]4 ([C@@] (C (C) (C (CC4) =O) C) ([H]) CC3) C

• Molecular Formula:

  C30H46O3

• Molecular Weight:

  454.68

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Atta-ur-Rahman, et al. Bioactive constituents from Boswellia papyrifera. J Nat Prod. 2005 Feb;68 (2) :189-93.|[2]Wu TT, et al. β-Elemonic acid inhibits the cell proliferation of human lung adenocarcinoma A549 cells: The roleof MAPK, ROS activation and glutathione depletion. Oncol Rep. 2016 Jan;35 (1) :227-34.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  COX-2

• CAS Number:

  28282-25-9