β-Elemonic acid

• Description :

  β-Elemonic acid is a triterpene isolated from Boswellia carterii. β-Elemonic acid induces cell apoptosis, reactive oxygen species (ROS) and COX-2 expression and inhibits prolyl endopeptidase. β-Elemonic acid exhibits anticancer and anti-inflammatory effects[1][2].

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Apoptosis; COX; Endogenous Metabolite; Prolyl Endopeptidase (PREP) ; Reactive Oxygen Species (ROS)

• Type :

  Natural Products

• Related Pathways :

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/β-elemonic-acid.html

• Purity :

  99.77

• Solubility :

  DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL

• Smiles :

  C[C@@]12C3=C(CC[C@]1([C@@]([C@@H](C(O)=O)CC/C=C(C)/C)([H])CC2)C)[C@@]4([C@@](C(C)(C(CC4)=O)C)([H])CC3)C

• Molecular Formula :

  C30H46O3

• Molecular Weight :

  454.68

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Atta-ur-Rahman, et al. Bioactive constituents from Boswellia papyrifera. J Nat Prod. 2005 Feb;68 (2) :189-93.|[2]Wu TT, et al. β-Elemonic acid inhibits the cell proliferation of human lung adenocarcinoma A549 cells: The roleof MAPK, ROS activation and glutathione depletion. Oncol Rep. 2016 Jan;35 (1) :227-34.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  COX-2

• CAS Number :

  [28282-25-9]