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Brevilin A

CAT: 0804-HY-N2959-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N2959-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Brevilin A is an orally active STAT3/JAK inhibitor (STAT3 IC50= 10.6 μM) . Brevilin A shows anti-tumor activity, anti-proliferative activity to cancer cells, and can induce apoptosis and autophagy[1][2].
CAS Number
16503-32-5
UNSPSC
12352005
Hazard Statement
H317
Target
Apoptosis; Autophagy; JAK; STAT
Type
Natural Products
Related Pathways
Apoptosis; Autophagy; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/brevilin-a.html
Purity
99.86
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C/C=C(C)\C(O[C@H]1[C@@]([C@@H]2C)([H])[C@@](OC2=O)([H])C[C@@H](C)[C@@]3([H])[C@]1(C(C=C3)=O)C)=O
Molecular Formula
C20H26O5
Molecular Weight
346.42
Precautions
H317
References & Citations
[1]Chen X, et al. Brevilin A, a novel natural product, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells. PLoS One. 2013 May 21;8 (5) :e63697.|[2]You P, et al. Brevilin A induces apoptosis and autophagy of colon adenocarcinoma cell CT26 via mitochondrial pathway and PI3K/AKT/mTOR inactivation. Biomed Pharmacother. 2018 Feb;98:619-625.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
STAT3

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