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Brevilin A

CAT: 0931-T4672-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T4672-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
16503-32-5
Target
Anti-infection|||Apoptosis|||JAK|||Autophagy|||STAT
Related Pathways
Autophagy|||Angiogenesis|||Stem Cells|||Apoptosis|||Microbiology/Virology|||Tyrosine Kinase/Adaptors|||Chromatin/Epigenetic|||JAK/STAT signaling
Purity
>99.99%
Bioactivity
Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT signal pathway by attenuating the JAKs activity and blocking STAT3 signaling (IC50 = 10.6 ?M) in Cancer Cells.Brevilin A induces apoptosis and autophagy via mitochondrial pathway and PI3K/AKT/mTOR inactivation in colon adenocarcinoma cell CT26.antitumour
Smiles
[H][C@@]12C[C@@H](C)[C@]3([H])C=CC(=O)[C@@]3(C)[C@@H](OC(=O)C(\C)=C/C)[C@]1([H])[C@H](C)C(=O)O2
Molecular Formula
C20H26O5
Molecular Weight
346.42
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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BISN0015-01Brevilin A
HY-N2959R-01Brevilin A (Standard)

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