Brevilin A

CAT: 0931-T4672-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-T4672-01Size:1 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

16503-32-5

Target

Anti-infection, Apoptosis, JAK, Autophagy, STAT

Related Pathways

Autophagy, Angiogenesis, Stem Cells, Apoptosis, Microbiology/Virology, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic, JAK/STAT signaling

Purity

>99.99%

Bioactivity

Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT signal pathway by attenuating the JAKs activity and blocking STAT3 signaling (IC50 = 10.6 μM) in Cancer Cells.Brevilin A induces apoptosis and autophagy via mitochondrial pathway and PI3K/AKT/mTOR inactivation in colon adenocarcinoma cell CT26.antitumour

Smiles

[H][C@@]12C[C@@H](C)[C@]3([H])C=CC(=O)[C@@]3(C)[C@@H](OC(=O)C(\C)=C/C)[C@]1([H])[C@H](C)C(=O)O2

Molecular Formula

C20H26O5

Molecular Weight

346.42

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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MBS3612729-01	Brevilin A
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Brevilin A

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