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Calcitroic acid

CAT: 0804-HY-N10508Size: 1 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-N10508Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Calcitroic acid is a vitamin D receptor (VDR) agonist that can activate VDR-mediated transcription. Calcitroic acid is the main metabolite of 1,25-dihydroxyvitamin D3, with the highest concentrations found in the liver and mucosa of mice, and it has metabolic stability and very low toxicity[1][2].
CAS Number
71204-89-2
UNSPSC
12352211
Target
Drug Metabolite; VD/VDR
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer; Metabolic Disease
Purity
85.0
Smiles
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CC(O)=O)([H])/C(CCC1)=C/C=C3C([C@H](C[C@@H](C\3)O)O)=C
Molecular Formula
C23H34O4
Molecular Weight
374.51
References & Citations
[1]Kelly A Teske, et al. Synthesis and Evaluation of Vitamin D Receptor-Mediated Activities of Cholesterol and Vitamin D Metabolites. Eur J Med Chem. 2016 Jan 6;109:238–246. |[2]R P Esvelt, et al. Calcitroic acid: biological activity and tissue distribution studies. Arch Biochem Biophys. 1981 Feb;206 (2) :403-13.
Shipping Conditions
Dry Ice
Storage Conditions
-80°C, protect from light, stored under nitrogen
Scientific Category
Natural Products
Clinical Information
No Development Reported

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