Cynomolgus Cadherin-17 / CDH17 Protein, Fc Tag (MALS verified)

• Background:

  Cadherin-17, also known as liver-intestine (LI) Cadherin, belongs to the cadherin family of calcium-dependent cell adhesion molecules. In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.

• Description:

  Cynomolgus Cadherin-17 Protein, Fc Tag (CA7-C5253) is expressed from human 293 cells (HEK293) . It contains AA Lys 30 - Thr 792 (Accession # A0A2K5X8I8-1) .

• Specifications:

  This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 111.1 kDa. The protein migrates as 130-150 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

• Accession Number:

  A0A2K5X8I8-1

• Expression Region:

  Lys 30 - Thr 792

• Host:

  HEK293

• Target:

  Cadherin-17

• Conjugation:

  Unconjugated

• Tag:

  C-Fc

• Source:

  Cynomolgus

• Stability:

  ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

• Endotoxin:

  1.0 EU per μg

• Purity:

  90%

• Bioactivity:

  Immobilized Cynomolgus Cadherin-17 Protein, Fc Tag (Cat. No. CA7-C5253) at 1 μg/mL (100 μL/well) can bind Anti-CDH17 antibody with a linear range of 2-63 ng/mL (QC tested).

• Format:

  Powder

• Buffer:

  PBS, pH7.4

• Additives:

  Trehalose

• Molecular Weight:

  111.1 kDa

• Shipping Conditions:

  RT

• Storage Conditions:

  -20°C

• Package Size:

  100ug*1

• Species:

  Cynomolgus