Biotinylated Cynomolgus Cadherin-17 / CDH17 Protein, His, Avitag™

• Background:

  Cadherin-17, also known as liver-intestine (LI) Cadherin, belongs to the cadherin family of calcium-dependent cell adhesion molecules. In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.

• Description:

  Biotinylated Cynomolgus Cadherin-17 Protein, His, Avitag (CA7-C82E9) is expressed from human 293 cells (HEK293) . It contains AA Gln 23 - Thr 784 (Accession # XP_005563762.2) .

• Specifications:

  This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™) . The protein has a calculated MW of 88.1 kDa. The protein migrates as 95-130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

• Accession Number:

  XP_005563762.2

• Expression Region:

  Gln 23 - Thr 784

• Host:

  HEK293

• Target:

  Cadherin-17

• Conjugation:

  Biotin-labeled

• Tag:

  C-10xHis & C-Avi

• Stability:

  ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

• Purity:

  90%

• Format:

  Powder

• Buffer:

  20 mM Tris, 150 mM NaCl, pH8.0

• Additives:

  Trehalose

• Molecular Weight:

  88.1 kDa

• Shipping Conditions:

  RT

• Storage Conditions:

  -20°C

• Package Size:

  200ug*1

• Species:

  Cynomolgus