Pheophorbide A

• Description:

  Pheophorbide A is an intermediate product in the chlorophyll degradation pathway. Pheophorbide A can be used as a photosensitizer. Pheophorbide A is a lymphatic vascular activator. Pheophorbide A has antitumor activity. Pheophorbide A can be used for human lymphatic vascular insufficiencies research[1][2][3].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Apoptosis

• Type:

  Natural Products

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/pheophorbide-a.html

• Purity:

  95.0

• Solubility:

  DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C) |Methanol : < 1 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C ([C@@H]1/C (C (NC (/C=C2C (CC) =C3C) =C4C) =C4C1=O) =C (N=C (/C=C (C (C) =C/5C=C) \NC5=C/C3=N/2) [C@H]6C) \[C@H]6CCC (O) =O) OC

• Molecular Formula:

  C35H36N4O5

• Molecular Weight:

  592.68

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Jihye Kim, et al. Pheophorbide a identified in an Eupatorium perfoliatum extract is a novel lymphatic vascular activator. Biomed Pharmacother. 2022 Mar;147:112664.|[2]Tang PM, et al. Pheophorbide a, an active compound isolated from Scutellaria barbata, possesses photodynamic activities by inducing apoptosis in human hepatocellular carcinoma. Cancer Biol Ther. 2006 Sep;5 (9) :1111-6.|[3]Ahn MY, et al. Pheophorbide a-mediated photodynamic therapy induces apoptotic cell death in murine oral squamous cell carcinoma in vitro and in vivo. Oncol Rep. 2012 Jun;27 (6) :1772-8.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  15664-29-6