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Oroxylin A

CAT: 0804-HY-N0560-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0560-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Oroxylin A is an active flavonoid compound with strong anti-cancer effects. Oroxylin A inhibits the IL-6/STAT3 pathway and NF-κB signaling, inhibits cell proliferation and induces apoptosis. Oroxylin A inhibits colitis-related carcinogenesis[1][2][3][4][5].
CAS Number
480-11-5
Product Name Alternative
Baicalein 6-methyl ether; 6-Methoxybaicalein
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; HIF/HIF Prolyl-Hydroxylase; Virus Protease
Type
Natural Products
Related Pathways
Anti-infection; Autophagy; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Oroxylin-A.html
Purity
99.87
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
O=C1C=C(C2=CC=CC=C2)OC3=CC(O)=C(OC)C(O)=C13
Molecular Formula
C16H12O5
Molecular Weight
284.26
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhao K, et al. Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells. J Hematol Oncol. 2015 Apr 23;8:41. http://www.ncbi.nlm.nih.gov/pubmed/25902914|[2]Dai Q, et al. Oroxylin A regulates glucose metabolism in response to hypoxic stress with the involvement of Hypoxia-inducible factor-1 in human hepatoma HepG2 cells. Mol Carcinog. 2015 Aug 10.|[3]Wei L, et al. Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1α destabilization. Cell Death Dis. 2015 Apr 9|[4]Sun X, et al. Oroxylin A Suppresses the Cell Proliferation, Migration, and EMT via NF-κB Signaling Pathway in Human Breast Cancer Cells. Biomed Res Int. 2019 Jun 23;2019:9241769.|[5]Yang X, et al. Oroxylin A inhibits colitis-associated carcinogenesis through modulating the IL-6/STAT3 signaling pathway. Inflamm Bowel Dis. 2013 Aug;19 (9) :1990-2000.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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