Quercetin-d3 (hydrate)

Quercetin-d3 (hydrate)

• UNSPSC Description: Quercetin-d3 hydrate is a deuterium labeled Quercetin hydrate (HY-18085A), a flavonoid which can stimulate recombinant SIRT1 and also a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1].
• Target Antigen: Apoptosis; Autophagy; Mitophagy; PI3K; Reactive Oxygen Species
• Type: Isotope-Labeled Compounds
• Related Pathways: Apoptosis;Autophagy;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB;PI3K/Akt/mTOR
• Field of Research: Cancer
• Solubility: DMSO : 30 mg/mL (ultrasonic;warming)
• Smiles: OC1=CC(O)=C2C(C(O)=C(OC2=C1)C3=C(C([2H])=C(C(O)=C3[2H])O)[2H])=O.O
• Molecular Weight: 323.27
• References & Citations: [1]Leyre Navarro-Núñez, et al. Effect of quercetin on platelet spreading on collagen and fibrinogen and on multiple platelet kinases. Fitoterapia. 2010 Mar;81(2):75-80. |[2]Yu XB, et al. Inhibitory effects of protein kinase C inhibitors on tumor necrosis factor induced bovine pulmonary artery endothelial cell injuries. Yao Xue Xue Bao. 1996;31(3):176-81.|[3]Yang F, et al. Combination of Quercetin and 2-Methoxyestradiol Enhances Inhibition of Human Prostate Cancer LNCaP and PC-3 Cells Xenograft Tumor Growth. PLoS One. 2015 May 26;10(5):e0128277.|[4]Tao Liu, et al. Quercetin alleviates kidney fibrosis by reducing renal tubular epithelial cell senescence through the SIRT1/PINK1/mitophagy axis. Life Sci. 2020 Jul 20;118116.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported