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Quercetin-d3 (hydrate)

CAT: 0804-HY-18085ASSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-18085ASSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Quercetin-d3 hydrate is a deuterium labeled Quercetin hydrate , a flavonoid which can stimulate recombinant SIRT1 and also a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1].
UNSPSC
12352005
Target
Apoptosis; Autophagy; Mitophagy; PI3K; Reactive Oxygen Species (ROS)
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR
Field of Research
Cancer
Purity
96.44
Solubility
DMSO : 30 mg/mL (ultrasonic;warming)
Smiles
OC1=CC(O)=C2C(C(O)=C(OC2=C1)C3=C(C([2H])=C(C(O)=C3[2H])O)[2H])=O.O
Molecular Formula
C15H9D3O8
Molecular Weight
323.27
References & Citations
[1]Leyre Navarro-Núñez, et al. Effect of quercetin on platelet spreading on collagen and fibrinogen and on multiple platelet kinases. Fitoterapia. 2010 Mar;81 (2) :75-80. |[2]Yu XB, et al. Inhibitory effects of protein kinase C inhibitors on tumor necrosis factor induced bovine pulmonary artery endothelial cell injuries. Yao Xue Xue Bao. 1996;31 (3) :176-81.|[3]Yang F, et al. Combination of Quercetin and 2-Methoxyestradiol Enhances Inhibition of Human Prostate Cancer LNCaP and PC-3 Cells Xenograft Tumor Growth. PLoS One. 2015 May 26;10 (5) :e0128277.|[4]Tao Liu, et al. Quercetin alleviates kidney fibrosis by reducing renal tubular epithelial cell senescence through the SIRT1/PINK1/mitophagy axis. Life Sci. 2020 Jul 20;118116.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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