T100-Mut

• Description :

  T100-Mut is a cell-permeable peptide whose N-terminus is conjugated with a myristoylated group to enable T100-Mut to penetrate and localize to the inner side of the plasma membrane, thus mimicking the topology of Tmem100-3Q. T100-Mut can alleviate TRPA1-mediated pain[1].

• UNSPSC :

  12352209

• Target :

  TRP Channel

• Type :

  Peptides

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/t100-mut.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CCCCCCCCCCCCCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)C)=O)CC1=CC=CC=C1)=O)CC(C)C)=O)CS)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CC(N)=O)=O)C(C)C)=O)C(C)C)=O)CC(C)C)=O)C)=O)[C@@H](C)O)=O)CCC(N)=O)=O)CO)=O)CCC(O)=O)=O)CCC(N)=O)=O)CCC(N)=O)=O)CCC(N)=O)=O)C(C)C)=O)CCCCN)=O)CCCCN)=O)CC(N)=O)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)C(C)C)=O)CCCCN)=O)CC2=CNC3=CC=CC=C23)=O

• Molecular Formula :

  C161H271N49O42S

• Molecular Weight :

  3597.30

• References & Citations :

  [1]Weng HJ, et al. Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain. Neuron. 2015 Feb 18;85 (4) :833-46.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported