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Esreboxetine

CAT: 0804-HY-14790Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-14790Size:1 Each
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Description
Esreboxetine ((S, S) -Reboxetine) is a selective norepinephrine reuptake inhibitor with activity in increasing urethral resistance. Esreboxetine has been reported to be effective in patients with stress urinary incontinence in a Phase IIa clinical study, achieving this effect by increasing urethral closure. The mechanism of action of esreboxetine involves inhibition of norepinephrine transporters in the central and peripheral nervous systems. The peripheral selectivity of esreboxetine helps it significantly increase urethral resistance without penetrating the brain[1].
CAS Number
98819-76-2
Product Name Alternative
(S, S) - (+) -Reboxetine
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/esreboxetine.html
Smiles
CCOC(C=CC=C1)=C1O[C@H]([C@]2([H])CNCCO2)C3=CC=CC=C3
Molecular Formula
C19H23NO3
Molecular Weight
313.39
References & Citations
[1]Erik H. F. Wong, Saeeduddin Ahmed, et al. Highly selective norepinephrine reuptake inhibitors and methods of using the same. WO2001001973A2 |[2]Fleishaker JC, Mucci M, Pellizzoni C, Poggesi I. Absolute bioavailability of reboxetine enantiomers and effect of gender on pharmacokinetics. Biopharm Drug Dispos. 1999 Jan;20 (1) :53-7. |[3]Herman BD, Fleishaker JC, Brown MT. Ketoconazole inhibits the clearance of the enantiomers of the antidepressant reboxetine in humans. Clin Pharmacol Ther. 1999 Oct;66 (4) :374-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3

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