PDDC

• Description:

  PDDC is a compound used to inhibit Alzheimer's disease. It is a nSMase2 inhibitor that can inhibit tau-induced nSMase2 activity and ceramide elevation, and slow the spread of tau in mouse models.

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319

• Target:

  Phospholipase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/pddc.html

• Concentration:

  10mM

• Purity:

  99.97

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CC1=C (C2=CC (OC) =C (C=C2) OC) N (N=C (C=C3N4C[C@@H] (CC4) NC (OC5=CC=CC=C5) =O) C) C3=N1

• Molecular Formula:

  C27H29N5O4

• Molecular Weight:

  487.55

• Precautions:

  H302, H315, H319

• References & Citations:

  [1]Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in an Alzheimer's disease mouse model

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2232878-43-0