PDDC

• Description :

  PDDC is a compound used to inhibit Alzheimer's disease. It is a nSMase2 inhibitor that can inhibit tau-induced nSMase2 activity and ceramide elevation, and slow the spread of tau in mouse models.

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319

• Target :

  Phospholipase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/pddc.html

• Concentration :

  10mM

• Purity :

  99.97

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CC1=C(C2=CC(OC)=C(C=C2)OC)N(N=C(C=C3N4C[C@@H](CC4)NC(OC5=CC=CC=C5)=O)C)C3=N1

• Molecular Formula :

  C27H29N5O4

• Molecular Weight :

  487.55

• Precautions :

  H302, H315, H319

• References & Citations :

  [1]Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in an Alzheimer's disease mouse model

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2232878-43-0]