U-PAR rabbit pAb

• Background:

  Function:Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form., similarity:Contains 3 UPAR/Ly6 domains., subunit:Monomer (Probable) . Interacts with MRC2.

• Description:

  Function: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. similarity: Contains 3 UPAR/Ly6 domains. subunit: Monomer (Probable). Interacts with MRC2.

• UniProt:

  Q03405

• Swiss Prot:

  Q03405

• Reactivity:

  Human; Rat; Mouse

• Immunogen:

  Synthesized peptide derived from human U-PAR

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; ELISA

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:1000-2000 ELISA 1:5000-20000

• Storage Conditions:

  -20°C/1 year

• Fragment:

  IgG

• Subcellular Location:

  Cell membrane . Cell projection, invadopodium membrane . Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner. .; [Isoform 1]: Cell membrane ; Lipid-anchor, GPI-anchor .; [Isoform 2]: Secreted .

• Other Product Names:

  Urokinase plasminogen activator surface receptor (U-PAR; uPAR; Monocyte activation antigen Mo3; CD antigen CD87)

• Gene ID (Human):

  5329