EGCG Octaacetate

EGCG Octaacetate

• CAS Number: 148707-39-5
• UNSPSC Description: EGCG Octaacetate (AcEGCG) is a proagent of Green tea epigallocatechin-3-gallate (EGCG). EGCG Octaacetate decreases the proinflammatory mediator levels by down-regulating of PI3K/Akt/NFκB phosphorylation and p65 acetylation. EGCG Octaacetate reduces colitis-driven colon cancer in mice. EGCG octaacetate is the potential antibacterial compound for gram-positive bacteria (GPB) and gram-negative bacteria (GNB)[1][2][3].
• Target Antigen: Bacterial
• Type: Reference compound
• Related Pathways: Anti-infection
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer; Infection; Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/egcg-octaacetate.html
• Purity: 98.42
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(C1=CC(OC(C)=O)=C(C(OC(C)=O)=C1)OC(C)=O)O[C@H]2[C@](C3=CC(OC(C)=O)=C(C(OC(C)=O)=C3)OC(C)=O)([H])OC4=CC(OC(C)=O)=CC(OC(C)=O)=C4C2
• Molecular Weight: 794.67
• References & Citations: [1]Wang CC, et al. Prodrug of green tea epigallocatechin-3-gallate (Pro-EGCG) as a potent anti-angiogenesis agent for endometriosis in mice. Angiogenesis. 2013 Jan;16(1):59-69.|[2]KalaiselviIgnasimuthu, et al. Enhanced bioaccessibility of green tea polyphenols and lipophilic activity of EGCG octaacetate on gram-negative bacteria. Volume 105, May 2019, Pages 103-109.|[3]Yi-Shiou Chiou, et al. Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently suppresses dextran sulfate sodium-induced colitis and colon tumorigenesis in mice. J Agric Food Chem. 2012 Apr 4;60(13):3441-51.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, protect from light)
• Clinical Information: No Development Reported