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TLK117

CAT: 0804-HY-13634B-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13634B-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TLK117, the active metabolite of TLK199, selective inhibits Glutathione S-transferase P1-1 (GSTP1-1) with a Ki of 0.4 μM for GSTP. TLK117 also competitively inhibits glyoxalase I with a Ki of 0.56 μM.
CAS Number
152684-53-2
Product Name Alternative
TER117
UNSPSC
12352209
Target
Glutathione S-transferase
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/TLK117.html
Purity
99.89
Solubility
DMSO : 150 mg/mL (ultrasonic)
Smiles
OC([C@@H](N)CCC(N[C@@H](CSCC1=CC=CC=C1)C(N[C@H](C2=CC=CC=C2)C(O)=O)=O)=O)=O
Molecular Formula
C23H27N3O6S
Molecular Weight
473.54
References & Citations
[1]The human glutathione transferase P1-1 specific inhibitor TER 117 designed for overcomingcytostatic-drug resistance is also a strong inhibitor of glyoxalase I. Mol Pharmacol. 2000 Mar;57 (3) :619-24.|[2]McMillan DH, et al. Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-S-transferase π. JCI Insight. 2016 Jun 2;1 (8) . pii: e85717.
Shipping Conditions
Room Temperature
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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