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DIPPA (hydrochloride)

CAT: 0804-HY-101223-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-101223-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DIPPA hydrochloride is an irreversible, long-lasting, selective and high affinity κ-opioid receptor antagonist. DIPPA hydrochloride can be used for the research of anxiety and antidepressant[1][2][3][4].
CAS Number
[155512-52-0]
UNSPSC
12352005
Hazard Statement
H301, H315, H319, H334, H335
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dippa-hydrochloride.html
Purity
99.7
Solubility
DMSO : 24 mg/mL (ultrasonic; warming)
Smiles
O=C(N([C@@H](C1=CC=CC(N=C=S)=C1)CN2CCCC2)C)CC3=CC=C(Cl)C(Cl)=C3.Cl
Molecular Formula
C22H24Cl3N3OS
Molecular Weight
484.87
Precautions
H301, H315, H319, H334, H335
References & Citations
[1]Jones DC, et al. Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis. Biochem Pharmacol. 2010;80 (10) :1478-1486.|[2]Carr GV, et al. Comparison of the kappa-opioid receptor antagonist DIPPA in tests of anxiety-like behavior between Wistar Kyoto and Sprague Dawley rats. Psychopharmacology (Berl) . 2010;210 (2) :295-302.|[3]Costello GF, et al. 2- (3,4-Dichlorophenyl) -N-methyl-N-[2- (1-pyrrolidinyl) -1-substituted- ethyl]-acetamides: the use of conformational analysis in the development of a novel series of potent opioid kappa agonists. J Med Chem. 1991;34 (1) :181-189.|[4]Chang AC, et al. kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists. J Med Chem. 1994;37 (26) :4490-4498.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
κ Opioid Receptor/KOR

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