DIPPA (hydrochloride)

• Description:

  DIPPA hydrochloride is an irreversible, long-lasting, selective and high affinity κ-opioid receptor antagonist. DIPPA hydrochloride can be used for the research of anxiety and antidepressant[1][2][3][4].

• UNSPSC:

  12352005

• Hazard Statement:

  H301, H315, H319, H334, H335

• Target:

  Opioid Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/dippa-hydrochloride.html

• Purity:

  99.7

• Solubility:

  DMSO : 24 mg/mL (ultrasonic; warming)

• Smiles:

  O=C(N([C@@H](C1=CC=CC(N=C=S)=C1)CN2CCCC2)C)CC3=CC=C(Cl)C(Cl)=C3.Cl

• Molecular Formula:

  C22H24Cl3N3OS

• Molecular Weight:

  484.87

• Precautions:

  H301, H315, H319, H334, H335

• References & Citations:

  [1]Jones DC, et al. Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis. Biochem Pharmacol. 2010;80 (10) :1478-1486.|[2]Carr GV, et al. Comparison of the kappa-opioid receptor antagonist DIPPA in tests of anxiety-like behavior between Wistar Kyoto and Sprague Dawley rats. Psychopharmacology (Berl) . 2010;210 (2) :295-302.|[3]Costello GF, et al. 2- (3,4-Dichlorophenyl) -N-methyl-N-[2- (1-pyrrolidinyl) -1-substituted- ethyl]-acetamides: the use of conformational analysis in the development of a novel series of potent opioid kappa agonists. J Med Chem. 1991;34 (1) :181-189.|[4]Chang AC, et al. kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists. J Med Chem. 1994;37 (26) :4490-4498.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  κ Opioid Receptor/KOR

• CAS Number:

  [155512-52-0]