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NSC339614 (potassium)

CAT: 0804-HY-148611Size: 1 EachDry Ice: NoHazardous: No
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Description
NSC339614 potassium is a selective GluN1/GluN2C and GluN1/GluN2D receptor enhancer with the activity of enhancing neuronal responses to specific NMDA receptors. NSC339614 potassium can selectively enhance the signaling of GluN1/GluN2C and GluN1/GluN2D receptors without affecting other NMDA receptors. The mechanism of action of NSC339614 potassium does not compete with agonists of L-glutamate or glycine, nor does it depend on membrane potential. The activity of NSC339614 potassium depends on the specific structure of the agonist ligand binding domain, showing its potential as a novel pharmacological agent for studying the function of NMDA receptor subtypes and providing new lead compounds for a variety of neurological diseases[1].
CAS Number
1135037-53-4
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nsc339614-potassium.html
Smiles
O=[N+](C1=CC=C2C3=NON=C3C=C(S(=O)(O[K])=O)C2=C1)[O-]
Molecular Formula
C10H4KN3O6S
Molecular Weight
333.32
References & Citations
[1]A novel family of negative and positive allosteric modulators of NMDA receptors
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

NSC339614 potassium
CAS Number1135037-53-4
PubChem CID5458772
IUPAC Namepotassium 7-nitrobenzo[g][2,1,3]benzoxadiazole-5-sulfonate
Molecular FormulaC10H4KN3O6S
Molecular Weight333.32
Topological Polar Surface Area150
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count8
Rotatable Bond Count0
Heavy Atom Count21
Formal Charge0
Complexity487
SMILES
C1=CC2=C(C=C1[N+](=O)[O-])C(=CC3=NON=C23)S(=O)(=O)[O-].[K+]
InChI
InChI=1S/C10H5N3O6S.K/c14-13(15)5-1-2-6-7(3-5)9(20(16,17)18)4-8-10(6)12-19-11-8;/h1-4H,(H,16,17,18);/q;+1/p-1
InChIKey
USKSVJAMFHMGIJ-UHFFFAOYSA-M
Chemical Structure
2D Structure
2D structure of NSC339614 potassium
CAS: 1135037-53-4
CID: 5458772
Formula: C10H4KN3O6S
MW: 333.32
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight333.32
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count8
Rotatable Bond Count0
Exact Mass332.94578751
Monoisotopic Mass332.94578751
Topological Polar Surface Area150 Ų
Heavy Atom Count21
Formal Charge0
Complexity487
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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