Formoterol-d3

CAT: 0804-HY-B0010AS-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0010AS-01Size:1 mg
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Description
Formoterol-d3 is deuterium labeled Arformoterol. Arformoterol ((R, R) -Formoterol), the (R, R) -enantiomer of Formoterol, is a long-acting β2-adrenergic receptor (β2-AR) agonist, with a Kd of 2.9 nM. Arformoterol can be used for the research of chronic obstructive pulmonary disease (COPD) [1][2].
CAS Number
[1198353-13-7]
UNSPSC
12352005
Hazard Statement
H332, H351, H361, H370, H372
Target
Adrenergic Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Purity
99.60
Solubility
DMSO : 2 mg/mL (ultrasonic; warming)
Smiles
[2H]C([2H])([2H])OC(C=C1)=CC=C1C[C@@H](C)NC[C@@H](C2=CC(NC=O)=C(C=C2)O)O
Molecular Formula
C19H21D3N2O4
Molecular Weight
347.42
Precautions
H332, H351, H361, H370, H372
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Cazzola M, et, al. Arformoterol tartrate in the treatment of COPD. Expert Rev Respir Med. 2010 Apr;4 (2) :155-62.|[3]Handley DA, et, al. Biological actions of formoterol isomers. Pulm Pharmacol Ther. 2002;15 (2) :135-45.|[4]Song W, et, al. Postexposure administration of a {beta}2-agonist decreases chlorine-induced airway hyperreactivity in mice. Am J Respir Cell Mol Biol. 2011 Jul;45 (1) :88-94.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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