3'-Deoxyuridine-5'-triphosphate (trisodium)

3'-Deoxyuridine-5'-triphosphate (trisodium)

• UNSPSC Description: 3'-Deoxyuridine-5'-triphosphate trisodium (3'-dUTP trisodium) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate trisodium strongly and competitively inhibits the incorporations of UTP into RNA with a Ki value of 2.0 μM[1].
• Target Antigen: DNA/RNA Synthesis; Endogenous Metabolite; Nucleoside Antimetabolite/Analog
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/3-deoxyuridine-5-triphosphate-trisodium.html
• Smiles: O=P(O)(O[Na])OP(OP(OC[C@@H](O1)C[C@@H](O)[C@@H]1N2C(NC(C=C2)=O)=O)(O[Na])=O)(O[Na])=O
• Molecular Weight: 534.09
• References & Citations: [1]M Saneyoshi, et al. Inhibitory Effects of 3'deoxycytidine 5'-triphosphate and 3'-deoxyuridine 5'-triphosphate on DNA-dependent RNA Polymerases I and II Purified From Dictyostelium Discoideum Cells. Nucleic Acids Res. 1981 Jul 10;9(13):3129-38.
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