3'-Deoxyuridine-5'-triphosphate

3'-Deoxyuridine-5'-triphosphate

• CAS Number: 69199-40-2
• UNSPSC Description: 3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into RNA with a Ki value of 2.0 μM[1].
• Target Antigen: DNA/RNA Synthesis; Endogenous Metabolite; Nucleoside Antimetabolite/Analog
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/3-deoxyuridine-5-triphosphate.html
• Solubility: 10 mM in DMSO
• Smiles: O=P(O)(O)OP(OP(OC[C@@H](O1)C[C@@H](O)[C@@H]1N2C(NC(C=C2)=O)=O)(O)=O)(O)=O
• Molecular Weight: 468.14
• References & Citations: [1]M Saneyoshi, et al. Inhibitory Effects of 3'deoxycytidine 5'-triphosphate and 3'-deoxyuridine 5'-triphosphate on DNA-dependent RNA Polymerases I and II Purified From Dictyostelium Discoideum Cells. Nucleic Acids Res. 1981 Jul 10;9(13):3129-38.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported