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Cucumarioside A2-2

CAT: 0804-HY-N13866Size: InquireDry Ice: NoHazardous: No
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CAT#:0804-HY-N13866Size:Inquire
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CAS Number
95499-80-2
UNSPSC Description
Cucumarioside A2-2 is a triterpene glycoside with antitumor activity. Cucumarioside A2-2 can induce mouse macrophage polarization toward the M1 phenotype. Cucumarioside A2-2 pretreated macrophages can effectively and selectively target and kill multiple types of cancer cells. Cucumarioside A2-2-induced M1 macrophages can effectively target and penetrate tumor tissues and improve the survival rate of mice in an allogeneic model. Exogenous activation of Cucumarioside A2-2 provides a useful model for the subsequent development of antitumor cell immunosuppression[1].
Target Antigen
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cucumarioside-a2-2.html
Smiles
C[C@@]12[C@@]3([C@@]([H])([C@@](OC3=O)(CCCC(C)=C)C)C(C2)=O)CC[C@]4(C1=CC[C@@]5([C@]4(C)CC[C@H](O[C@@H]6OC[C@H]([C@@H]([C@H]6O[C@@H]7O[C@@H]([C@H]([C@@H]([C@H]7O[C@@H]8OC[C@H]([C@@H]([C@H]8O)O)O)O)O[C@@H]9O[C@@H]([C@H]([C@@H]([C@H]9O)O[C@@H]%10O[C@@H]([C@H]([C@@H]([C@H]%10O)OC)O)CO)O)CO)C)O)OS(=O)(O[Na])=O)C5(C)C)[H])[H]
Molecular Weight
1319.39
References & Citations
[1]Holothurian triterpene glycoside cucumarioside A2-2 induces macrophages activation and polarization in cancer immunotherapy
Shipping Conditions
Room temperature
Clinical Information
No Development Reported

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