RegisterLogin

TBE 31

CAT: 0804-HY-141439Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-141439Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
TBE 31 is a potent and orally active NQO1 inducer with an Dm value of 1.1 nM. TBE 31 also is a potent Nrf2 activator. TBE 31 reacts with cysteines of Keap1, impairing its ability to target nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) for degradation. TBE 31 shows cytoprotective effects[1][2].
CAS Number
[936475-62-6]
UNSPSC
12352211
Target
Keap1-Nrf2; Quinone Reductase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tbe-31.html
Smiles
C#C[C@]12C([C@@]3([C@@](C(C)(C(C(C#N)=C3)=O)C)([H])CC1)C)=CC(C(C#N)=C2)=O
Molecular Formula
C21H18N2O2
Molecular Weight
330.38
References & Citations
[1]Dinkova-Kostova AT, et al. An exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with Keap1. J Biol Chem. 2010 Oct 29;285 (44) :33747-55. |[2]Kostov RV, et al. Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis (cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action. Biochem Biophys Res Commun. 2015 Sep 25;465 (3) :402-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-K1016-01TBE Powder (1 L of 1x)
HY-148782HBV-IN-31
HY-164427SHP2-IN-31
HY-161942PCSK9-IN-31
HY-P5670Maximin 31
HY-164713-01PARP1-IN-31
HY-111655-01SKA-31
HY-174250PTP1B-IN-31
HY-163441BChE-IN-31
HY-133558-01VII-31

Alternative Products

CatalogName
APPDE 300Plasmid DNA Extraction Mini Kit (300prep) (sample size:1~3 ml culture)
APGCK 050GEL/PCR Purification Mini Kit (50prep)
APPCK 200PCR Clean-Up Mini Kit (200prep)
APGPK 200GEL Purification Mini Kit (200prep)
APPGK 100Plant Genomic DNA Extraction Mini Kit (100prep)
APGDC 050FavorPrep Genomic DNA Clean-Up Kit (50prep)
APGDC 200FavorPrep Genomic DNA Clean-Up Kit (200prep)
APVNK 200Viral Nucleic Acid Extraction Kit (200prep), (With Carrier RNA, for low viral load specimen using carrier RNA)
APEBD 002-3Alphagen EtBr Destroyer Sprayer
APRND 001-1Alphagen RNase Destroyer Sprayer

Popular Products