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Mitraphylline (Standard)

CAT: 0804-HY-N6946RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N6946RSize:1 Each
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Description
Mitraphylline (Standard) is the analytical standard of Mitraphylline. This product is intended for research and analytical applications. Mitraphylline is the major pentacyclic oxindolic alkaloid presented in Uncaria tomentosa. Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils. Mitraphylline exhibits antiproliferative activity in human glioma and neuroblastoma cell lines. Mitraphylline can inhibit interleukin release in vivo[1][2][3].
CAS Number
509-80-8
UNSPSC
12352005
Target
Interleukin Related; NF-κB; Reference Standards
Type
Reference Standards
Related Pathways
Immunology/Inflammation; NF-κB; Others
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mitraphylline-standard.html
Smiles
O=C1NC2=C([C@@]13CCN4C[C@@]5([C@@H](OC=C([C@]5(C[C@]43[H])[H])C(OC)=O)C)[H])C=CC=C2
Molecular Formula
C21H24N2O4
Molecular Weight
368.43
References & Citations
[1]Montserrat-de la Paz S, et al. Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils. Phytomedicine. 2016 Feb 15;23 (2) :141-8.|[2]Rojas-Duran, R., et al., (2012) . Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark. Journal of ethnopharmacology, 143 (3), 801–804.|[3]García Prado, E., et al., (2007) . Antiproliferative effects of mitraphylline, a pentacyclic oxindole alkaloid of Uncaria tomentosa on human glioma and neuroblastoma cell lines. Phytomedicine : international journal of phytotherapy and phytopharmacology, 14 (4), 280–284.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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