Emapticap pegol (sodium)

• Description:

  Emapticap pegol sodium is a inhibitor of pro-inflammatory chemokine C-C motif-ligand 2 (CCL2) . Emapticap pegol sodium is a 40-nucleotide oligonucleotide aptamer, displays different Spiegelmers (L-RNA aptamer) isform in human (NOX-E36) and mouse (mNOX-E36) [1][2][3].

• Product Name Alternative:

  NOX-E36 (sodium)

• UNSPSC:

  12352208

• Target:

  CCR

• Type:

  Oligonucleotides

• Related Pathways:

  GPCR/G Protein; Immunology/Inflammation

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/emapticap-pegol-sodium.html

• Purity:

  91.38

• Solubility:

  10 mM in H2O

• Smiles:

  [Emapticap pegol (sodium) ]

• References & Citations:

  [1]Menne J, et al. C-C motif-ligand 2 inhibition with emapticap pegol (NOX-E36) in type 2 diabetic patients with albuminuria. Nephrol Dial Transplant. 2017 Feb 1;32 (2) :307-315. |[2]Rodrigo, et al. Effects of CCL2/CCR2 Blockade in Acute Myeloid Leukemia. Blood. |[3]Boels MGS, et al. Systemic Monocyte Chemotactic Protein-1 Inhibition Modifies Renal Macrophages and Restores Glomerular Endothelial Glycocalyx and Barrier Function in Diabetic Nephropathy. Am J Pathol. 2017 Nov;187 (11) :2430-2440.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Oligonucleotides

• Clinical Information:

  Phase 2