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Lunarine

CAT: 0804-HY-129278Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-129278Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lunarine is an alkaloid, which can be isolated from the seeds of kale (Lunaria annua) . Lunarine lowers the blood pressure, stimulates small intestinal motility, inhibits spontaneous contractions of uterus and nervous system, and exhibits an acute toxicity with LD50 of 62.3 mg/kg in dogs and rabbits. Lunarine exhibits antiparasitic activity through a competitive inhibition of protozoan oxidoreductase trypanothione reductase (TryR) with Ki of 304 μM[1].
CAS Number
24185-51-1
UNSPSC
12352005
Target
Parasite
Type
Natural Products
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/lunarine.html
Smiles
O=C1C[C@]2([H])[C@]3(CC1)C4=CC(/C=C/C(NCCCNCCCCNC(/C=C/3)=O)=O)=CC=C4O2
Molecular Formula
C25H31N3O4
Molecular Weight
437.53
References & Citations
[1]Hamilton CJ, et al., Time-dependent inhibitors of trypanothione reductase: analogues of the spermidine alkaloid lunarine and related natural products. Bioorg Med Chem. 2006 Apr 1;14 (7) :2266-78.|[2]HENDERSON FG, et al., The pharmacology of lunarine, the alkaloid of Lunaria biennis. J Am Pharm Assoc Am Pharm Assoc. 1950 Sep;39 (9) :516-9.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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