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Canakinumab

CAT: 0804-HY-108810-01Size: 1 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-108810-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Canakinumab (ACZ885) is a recombinant human anti-IL-1β monoclonal antibody. Canakinumab shows IC50 values of 43.6 and 40.8 pM for human and marmoset IL-1β, respectively. The mode of action of canakinumab is based on the neutralization of IL-1β signaling, resulting in suppression of inflammation related to disorders of autoimmune origin[1][2].
CAS Number
914613-48-2
Product Name Alternative
Ilaris; ACZ 885
UNSPSC
12352203
Target
Interleukin Related
Type
Inhibitory Antibodies
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/canakinumab.html
Purity
99.64
Solubility
10 mM in DMSO
Smiles
[Canakinumab]
Molecular Weight
(145.5 kDa)
References & Citations
[1]Dhimolea E. Canakinumab. MAbs. Epub 2010 Jan 15. |[2]Rondeau JM, et al. The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1β. MAbs. 2015;7 (6) :1151-60.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Launched

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