PI3Kδ-IN-15

PI3Kδ-IN-15

• CAS Number: 870281-17-7
• UNSPSC Description: PI3Kδ-IN-15 (compound 6b) is a selective PI3Kδ inhibitor with an IC50 of 0.5 nM for p110δ. PI3Kδ-IN-15 inhibits PI3Kδ with >30-fold higher potency than PI3Kγ, PI3Kβ, and PI3Kα[1].
• Target Antigen: PI3K
• Type: Reference compound
• Related Pathways: PI3K/Akt/mTOR
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pi3kδ-in-15.html
• Purity: 99.52
• Solubility: DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O=C1N(C2=CC=CC=C2)C([C@@H](NC3=C4N=CNC4=NC=N3)C)=NC5=C1C(F)=CC=C5
• Molecular Weight: 401.40
• References & Citations: [1]Yeon Su Kim, et al. Synthesis and biological evaluation of novel purinyl quinazolinone derivatives as PI3Kδ-specific inhibitors for the treatment of hematologic malignancies. Bioorg Med Chem. 2021 Sep 1;45:116312.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported