(R,S,S)-VH032

(R,S,S)-VH032

• CAS Number: 2230826-33-0
• UNSPSC Description: (R,S,S)-VH032 is Ligand for E3 Ligase used in the synthesis of PROTACs. VH032 is a VHL ligand and VHL/HIF-1α interaction inhibitor that recruits von Hippel-Lindau (VHL) proteins. (R,S,S)-VH032 synthesizes the tau-targeting small molecule PROTAC C004019 (HY-138669)[1].
• Target Antigen: Ligands for E3 Ligase
• Type: Reference compound
• Related Pathways: PROTAC
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/r-s-s-vh032.html
• Smiles: CC1=C(SC=N1)C(C=C2)=CC=C2CNC([C@@H]3N(C[C@H](C3)O)C([C@@H](N)C(C)(C)C)=O)=O
• Molecular Weight: 430.56
• References & Citations: [1]Wang W, et al. A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models. Theranostics. 2021 Mar 11;11(11):5279-5295.
• Shipping Conditions: Room Temperature