Products for Research Use Only
RegisterLogin

(R, S, S) -VH032

CAT: 0804-HY-138678-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-138678-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
(R, S, S) -VH032 is Ligand for E3 Ligase used in the synthesis of PROTACs. VH032 is a VHL ligand and VHL/HIF-1α interaction inhibitor that recruits von Hippel-Lindau (VHL) proteins. (R, S, S) -VH032 synthesizes the tau-targeting small molecule PROTAC C004019.
CAS Number
2230826-33-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/r-s-s-vh032.html
Purity
98.99
Solubility
10 mM in DMSO
Smiles
CC1=C(SC=N1)C(C=C2)=CC=C2CNC([C@@H]3N(C[C@H](C3)O)C([C@@H](N)C(C)(C)C)=O)=O
Molecular Formula
C22H30N4O3S
Molecular Weight
430.56
Precautions
H302, H315, H319, H335
References & Citations
[1]Wang W, et al. A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models. Theranostics. 2021 Mar 11;11 (11) :5279-5295.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)

Related Products

CatalogName
HY-138678B(S, R, R) -VH032
HY-W998247(S, R, R) -VH032 (hydrochloride)
HY-120217A(S, S, S) -VH032
HY-176302(S, S, S) -VH032-cyclopropane-F
HY-163904(S, R, R) -VH032-CO-C3-CONH-C2-PEG3-OH
HY-176338(S, S, S) -VH032-cyclopropane-F-C4-aldehyde
HY-172298(R, S, S, S) -Orlistat
HY-78931A-01(R, S, S, R, S) -Boc-Dap-NE
HY-78931C-01(S, S, R, S, R) -Boc-Dap-NE
HY-170348-01(S) - (S, R, S, R) -AHPC-Me-N3

Alternative Products

CatalogName
BUP14366-01VH032
YID83654-01Vh032 thiol
OR1033761-01VH032-OH
T17230-01VH032-PEG3-acetylene
MBS3615552-01VH032-cyclopropane-F
A19857-10VH032 thiol 10mg
GTR19346227-01BODIPY FL VH032
MBS3615290-01VH032-PEG4-NH2
abx282908-01VH032 amine HCl
A19857-100VH032 thiol 100mg

Popular Products