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(R, S, S) -VH032

CAT: 0804-HY-138678-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-138678-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(R, S, S) -VH032 is Ligand for E3 Ligase used in the synthesis of PROTACs. VH032 is a VHL ligand and VHL/HIF-1α interaction inhibitor that recruits von Hippel-Lindau (VHL) proteins. (R, S, S) -VH032 synthesizes the tau-targeting small molecule PROTAC C004019.
CAS Number
2230826-33-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/r-s-s-vh032.html
Purity
98.99
Solubility
10 mM in DMSO
Smiles
CC1=C(SC=N1)C(C=C2)=CC=C2CNC([C@@H]3N(C[C@H](C3)O)C([C@@H](N)C(C)(C)C)=O)=O
Molecular Formula
C22H30N4O3S
Molecular Weight
430.56
Precautions
H302, H315, H319, H335
References & Citations
[1]Wang W, et al. A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models. Theranostics. 2021 Mar 11;11 (11) :5279-5295.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)

Chemical Information

(R,S,S)-VH032
CAS Number2230826-33-0
PubChem CID135157027
IUPAC Name(2R,4S)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
Molecular FormulaC22H30N4O3S
Molecular Weight430.6
XLogP2.1
Topological Polar Surface Area137
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Heavy Atom Count30
Formal Charge0
Complexity618
SMILES
CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@H]3C[C@@H](CN3C(=O)[C@H](C(C)(C)C)N)O
InChI
InChI=1S/C22H30N4O3S/c1-13-18(30-12-25-13)15-7-5-14(6-8-15)10-24-20(28)17-9-16(27)11-26(17)21(29)19(23)22(2,3)4/h5-8,12,16-17,19,27H,9-11,23H2,1-4H3,(H,24,28)/t16-,17+,19+/m0/s1
InChIKey
ZLOXMSNKPDWMEF-YQVWRLOYSA-N
Chemical Structure
2D Structure
2D structure of (R,S,S)-VH032
CAS: 2230826-33-0
CID: 135157027
Formula: C22H30N4O3S
MW: 430.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight430.6
XLogP32.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass430.20386201
Monoisotopic Mass430.20386201
Topological Polar Surface Area137 Ų
Heavy Atom Count30
Formal Charge0
Complexity618
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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BUP14366-01VH032
YID83654-01Vh032 thiol
OR1033761-01VH032-OH
T17230-01VH032-PEG3-acetylene
MBS3615552-01VH032-cyclopropane-F
A19857-10VH032 thiol 10mg
GTR19346227-01BODIPY FL VH032
MBS3615290-01VH032-PEG4-NH2
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A19857-100VH032 thiol 100mg

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