Azelaprag

• Description:

  Azelaprag (Example 263.0) is a candidate active molecule for an Apelin receptor agonist with an EC50 of 0.32 nM for the apelin receptor[1].

• Product Name Alternative:

  AMG 986

• UNSPSC:

  12352005

• Target:

  Apelin Receptor (APJ)

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/Azelaprag.html

• Purity:

  99.94

• Solubility:

  DMSO : 5 mg/mL (ultrasonic)

• Smiles:

  O=S(NC1=NN=C(C2=CN=CC(C)=C2)N1C(C(OC)=CC=C3)=C3OC)([C@@H](C)[C@@H](C4=NC=C(C)C=N4)C)=O

• Molecular Formula:

  C25H29N7O4S

• Molecular Weight:

  523.61

• References & Citations:

  [1]WO2016187308A1.|[2]Ason B, et.al. Cardiovascular response to small-molecule APJ activation. JCI Insight. 2020 Apr 23;5 (8) :e132898.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• CAS Number:

  [2049980-18-7]