Bacterial Sortase Substrate III, Abz/DNP (TFA)

• UNSPSC Description:

  Bacterial Sortase Substrate III, Abz/DNP TFA is an internally quenched fluorescent peptide substrate. Staphylococcus aureus transpeptidase sortase A (SrtA) reacts with its native substrate Bacterial Sortase Substrate III, Abz/DNP, cleaving it and catalyzing the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Cleavage of this substrate can be monitored at Ex/Em=320 nm/420 nm.

• Target Antigen:

  Fluorescent Dye

• Type:

  Peptides

• Related Pathways:

  Others

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/bacterial-sortase-substrate-iii-abz-dnp-tfa.html

• Purity:

  96.63

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL (ultrasonic)

• Smiles:

  O=C([C@@H](NC(C1=C(C=CC=C1)N)=O)CC(C)C)N2[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N)=O)CCCCNC3=C(C=C(C=C3)[N+]([O-])=O)[N+]([O-])=O)=O)=O)[C@@H](C)O)=O)CCC(O)=O)=O)CCC2.OC(C(F)(F)F)=O.[x]

• References & Citations:

  [1]Zhang J, et al. Antiinfective therapy with a small molecule inhibitor of Staphylococcus aureus sortase. Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13517-22.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported